Danofloxain Mesylate Injection

[main component] daprofloxacin mesylate
[properties] this product is light yellow green or yellow green clear liquid.
[pharmacological action]
Pharmacodynamics dafloxacin mesylate belongs to fluoroquinolones for animals. It can inhibit bacterial DNA replication and transcription by acting on the DNA gyrasea subunit of bacteria. It has excellent antibacterial activity against Escherichia coli, Salmonella, Shigella and other gram-negative bacteria of Enterobacteriaceae; It has good to moderate antibacterial activity against Staphylococcus and mycoplasma; It has little or no antibacterial activity against Streptococcus (especially group D), Enterococcus and anaerobic bacteria.
Pharmacokinetics the drug was absorbed rapidly and completely by intramuscular injection and subcutaneous injection. The bioavailability of intramuscular injection in pigs was 78% -101%. This product is mainly excreted through the kidney. After intramuscular injection in pigs, 43% to 51% of the original drug can be excreted in the urine respectively. The half-life of intravenous injection in pigs was 8 hours; The half-life of intramuscular injection was 6.8 hours.
[drug interactions]
① It has synergistic antibacterial effect with aminoglycosides and broad-spectrum penicillin.
② Ca2+, mg2+, fe3+, al3+and other metal ions can chelate with this product and affect its absorption.
③ It can inhibit liver drug enzymes, reduce the metabolism of other drugs (such as theophylline and caffeine), reduce the clearance rate, increase the blood drug concentration, and even cause poisoning symptoms.
④ When combined with probenecid, the excretion of probenecid in renal tubules was inhibited due to competition for the same carrier, and the half-life was prolonged.
[function and use] fluoroquinolones. It is mainly used for pig bacterial and mycoplasma infection.
[usage and dosage] intramuscular injection: 0.125-0.25ml per 1kg body weight of pigs. Once a day for 3 consecutive days.
[adverse reactions]
(1) It can cause cartilage degeneration in young animals, affect bone development and cause claudication and pain.
(2) The reactions of digestive system include vomiting, anorexia, diarrhea, etc.
(3) Skin reactions include erythema, pruritus, urticaria and photosensitive reaction.
[precautions]
(1) Do not use it in the same day as the preparation containing iron.
(2) Pregnant and lactating cows are forbidden.
[drug withdrawal period] pig 25 days.
[Specification] 10ml:0.1g calculated according to dafloxacin
[package] 10ml × 10 pieces/box