10 to 1 sulfamonomethoxine sodium injection

[main ingredient] sulfamonomethoxine sodium
[property] this product is colorless to light yellow clear liquid.
[pharmacological action] this product is a broad-spectrum antibacterial drug. It is a sulfonamide drug with the strongest antibacterial activity in vivo and in vitro. It has a strong inhibitory effect on most Gram-positive bacteria and Gram-negative bacteria, and bacteria develop resistance to this drug slowly. It has good antibacterial effect on Gram-positive bacteria and Gram-negative bacteria such as Streptococcus pyogenes, Salmonella and pneumonia. Sulfonamides are similar to p-aminobenzoic acid in structure. They can compete with aminobenzoic acid for dihydrofolate synthase in bacteria, hinder the synthesis of dihydrofolate, and ultimately affect the synthesis of nucleic acid and inhibit the growth and reproduction of bacteria. The effect of sulfonamides can be antagonized by aminobenzoic acid and its derivatives (procaine, tetracaine). In addition, pus and tissue decomposition products can also provide essential substances for bacterial growth, and have antagonistic effect with sulfonamides.
[drug interactions]
(1) When combined with benzylaminopyrimidine (antibacterial synergist), it can produce synergistic effect.
(2) Some drugs containing p-aminobenzoyl, such as procaine and tetracaine, can produce p-aminobenzoic acid in vivo. Yeast tablets also contain p-aminobenzoic acid required for bacterial metabolism, which can be reduced when combined.
(3) When used with diuretics such as thiazide or furosemide, it can aggravate renal toxicity.
[function and use] sulfonamides. It can be used for infection of sensitive bacteria and Toxoplasma gondii in pigs.
[usage and dosage] intravenous injection: one dose, 0.5ml per 1kg body weight of livestock. 1-2 times a day for 2-3 days.
[adverse reactions]
(1) Sulfanilamide or its metabolites can precipitate in urine, which is more likely to crystallize when administered at high dose or low dose for a long time, causing crystalline urine, hematuria or renal tubular obstruction.
(2) Intravenous injection in horses can cause temporary paralysis.
(3) Sulfanilamide injection is a strong alkaline solution with strong irritation to tissues.
[precautions]
(1) This product can precipitate crystals in the presence of acids, so it should not be diluted with 5% glucose solution.
(2) Long term or large dose application is easy to cause crystalline urine, so sodium bicarbonate should be applied at the same time, and a large amount of water should be given to the affected animals.
(3) In case of allergic reaction or other serious adverse reactions, stop the drug immediately and give symptomatic treatment.
[drug withdrawal period] 28 days for livestock; The milk abandonment period is 7 days.
[Specification] 10ml ∶ 1g