Flunixin meglumine injection

[main ingredient] flunixin meglumine
[properties] this product is colorless or light yellow clear liquid.
[pharmacological action]
Pharmacodynamics flunixin meglumine is a potent cyclooxygenase inhibitor with analgesic, antipyretic, anti-inflammatory and anti rheumatic effects. The analgesic effect is caused by inhibiting the synthesis of peripheral prostaglandins or their pain sensitizing substances or their combined action, thereby blocking the transmission of pain impulse. The anti-inflammatory effect of peripheral tissue may be caused by inhibiting cyclooxygenase, reducing the formation of prostaglandin precursors, and inhibiting other mediators to cause local inflammatory reaction.
After a single intramuscular injection (2.2mg/kg body weight), the plasma elimination half-life was 3-4 hours, the peak concentration was 2.94 μ g/ml, the peak time was 0.4 hours, and the drug could still be detected in the blood 18 hours after administration. The apparent distribution volume was 2.0l/kg, and the bioavailability of a single cervical injection was 87%.
[drug interactions]
(1) Do not use flunixin meglumine with other non steroidal anti-inflammatory drugs at the same time, because it will aggravate the toxic and side effects on the gastrointestinal tract, such as ulcers, bleeding, etc.
(2) Due to the high binding rate of plasma protein, when combined with other drugs, flunixin meglumine may replace other drugs combined with plasma protein or be replaced by other drugs, resulting in the enhanced effect of the replaced drugs and even toxicity.
(3) Combined with antibiotics, it is used for adjuvant treatment of sow agalactiae syndrome.
[function and use] antipyretic analgesic and anti-inflammatory drugs. It is used for febrile, inflammatory diseases, muscle pain and soft tissue pain of livestock and small animals.
[usage and dosage] intramuscular and intravenous injection: one dose, 0.4ml per 10kg body weight of beef cattle and pigs; 0.2-0.4ml for dogs and cats. One to two times a day for no more than five consecutive days.
[adverse reaction] intramuscular injection can stimulate the local area. Long term high-dose use of this product may cause gastric ulcer and renal function damage in animals.
[precautions] animals with peptic ulcer should be used with caution.
[drug withdrawal period] 28 days for cattle and pigs.
[Specification] 10ml:0.5g based on c14h11f3n2o2
[package] 10ml × 10 pieces/box