Flunixin meglumine injection
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Classification:
Detailed Description
【Main components】Flunixin meglumine
【Appearance】This product is a colorless or light yellow transparent liquid.
【Pharmacological action】
Pharmacodynamics: Flunixin meglumine is a potent cyclooxygenase inhibitor with analgesic, antipyretic, anti-inflammatory, and anti-rheumatic effects. The analgesic effect is achieved by inhibiting the synthesis of peripheral prostaglandins or their hyperalgesic substances, or their combined action, thereby blocking the transmission of pain impulses. The anti-inflammatory effect on peripheral tissues may be due to the inhibition of cyclooxygenase, the reduction of prostaglandin precursor formation, and the inhibition of other mediators that cause local inflammatory responses.
Pharmacokinetics: After a single intramuscular injection in pigs (2.2 mg/kg body weight), the plasma elimination half-life is 3-4 hours, the peak concentration is 2.94 μg/mL, the peak time is 0.4 hours, and the drug can still be detected in the blood after 18 hours of administration. The apparent volume of distribution is 2.0 L/kg, and the bioavailability of a single cervical injection is 87%.
【Drug interactions】
(1) Concomitant use of flunixin meglumine with other non-steroidal anti-inflammatory drugs will aggravate the gastrointestinal toxicity, such as ulcers and bleeding.
(2) Due to its high plasma protein binding rate, when used in combination with other drugs, flunixin meglumine may displace other drugs bound to plasma proteins or be displaced by other drugs, leading to enhanced effects of the displaced drugs, or even toxicity.
(3) Combined with antibiotics for the adjuvant treatment of agalactia in sows.
【Action and use】Antipyretic, analgesic, and anti-inflammatory drug. Used for livestock and small animals with febrile and inflammatory diseases, myalgia, and soft tissue pain.
【Usage and dosage】Intramuscular injection: Single dose, per 10 kg body weight, cattle and pigs 0.4 ml; dogs and cats 0.2-0.4 ml. Once or twice a day, for no more than 5 days.
【Adverse reactions】Intramuscular injection has local irritation. Long-term, high-dose use of this product may lead to gastric ulcers and kidney damage in animals.
【Precautions】Use with caution in patients with peptic ulcers.
【Withdrawal period】Cattle and pigs 28 days.
【Specifications】Calculated as C14H11F3N2O2 100ml:5g
【Packaging】100ml × 90 bottles/box
【Storage】Protect from light and store in a tightly closed container.
【Shelf life】Two years
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Address: Jinghe Xincheng Jingyong Road Middle Industrial Park, Xixian New District, Shaanxi Province
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