
Gentamicin sulfate injection
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Detailed Description
【Main components】Gentamicin sulfate
【Appearance】This product is a colorless to slightly yellow or yellowish-green transparent liquid.
【Pharmacological effects】
Pharmacodynamics: Gentamicin is an aminoglycoside antibiotic that has antibacterial effects on a variety of Gram-negative bacteria (such as Escherichia coli, Klebsiella, Proteus, Pseudomonas aeruginosa, Pasteurella, Salmonella, etc.) and Staphylococcus aureus (including β-lactamase-producing strains). Most cocci (pyogenic streptococci, pneumococci, enterococci, etc.), anaerobic bacteria (Bacteroides or Clostridium), tubercle bacilli, rickettsiae and fungi are resistant to this product.
Pharmacokinetics: After intramuscular injection, it is rapidly and completely absorbed, reaching peak blood concentration within 0.5~1 hour. The bioavailability of subcutaneous or intramuscular injection exceeds 90%. It is mainly excreted by glomerular filtration, and the excretion accounts for 40%~80% of the administered dose. Elimination half-life after intramuscular injection: horse 1.8~3.3 hours, pony 2.2~2.7 hours, dog and cat 0.5~1.5 hours, cow and pig 1 hour, rabbit 1~2 hours, sheep, buffalo, cattle and dairy goat 2.3~3.2 hours.
【Drug interactions】
(1) The combined use of gentamicin with tetracycline, erythromycin, etc. may result in antagonistic effects.
(2) Combined use with cephalosporins, dextran, potent diuretics (such as furosemide, etc.), erythromycin, etc., can enhance the ototoxicity of this product.
(3) Skeletal muscle relaxants (such as succinylcholine chloride, etc.) or drugs with this effect can enhance the neuromuscular blocking effect of this product.
【Action and use】Aminoglycoside antibiotics. Used for Gram-negative and positive bacterial infections.
【Usage and dosage】Intramuscular injection: Single dose, per 1 kg body weight, livestock 0.05~0.1 ml; dog, cat 0.075~0.125 ml. Twice a day, for 2~3 consecutive days.
【Adverse reactions】
(1) Ototoxicity. Often causes damage to the vestibular system of the ear, which can worsen with the accumulation of continuously administered drugs and is dose-dependent.
(2) Allergic reactions have occasionally been observed. Cats are more sensitive, and normal doses can cause nausea, vomiting, drooling, and ataxia.
(3) Canine doses can cause neuromuscular conduction blockade. After general anesthesia for canine and feline surgery, when penicillin is used to prevent infection, unexpected deaths often occur.
(4) Can cause reversible nephrotoxicity.
【Precautions】
(1) Gentamicin can be used in combination with β-lactam antibiotics to treat severe infections, but there are incompatibilities when mixed in vitro.
(2) In combination with penicillin, it has a synergistic effect on streptococci.
(3) Combined use with cephalosporins may enhance nephrotoxicity.
【Withdrawal period】40 days for pigs, cattle, and sheep.
【Specifications】100ml: 4.0g (4 million units)
【Packaging】100ml×90 bottles/box
【Storage】Sealed and stored in a cool, dark place.
【Shelf life】Two years
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