Ivermectin Injection

【Main components】Ivermectin
【Appearance】This product is a colorless or almost colorless, clear, slightly viscous liquid.

【Pharmacological action】
Pharmacodynamics: Ivermectin has a good killing effect on internal nematodes and ectoparasites. Its anthelmintic mechanism is to promote the release of γ-aminobutyric acid (GABA) from presynaptic neurons, thereby opening GABA-mediated chloride channels. Ivermectin also has selective and high affinity for glutamate-mediated chloride channels near the GABA-mediated site in invertebrate nerve and muscle cells, thereby interfering with signal transmission between nerves and muscles, causing the worms to relax and paralyze, leading to the death or expulsion of the worms. The inhibitory interneurons and excitatory motor neurons of nematodes are its sites of action, while the sites of action in arthropods are neuromuscular junctions.

The removal rate of adult and fourth-stage larvae of Haemonchus, Ostertagia, Cooperia, Trichostrongylus (including Trichostrongylus axei), Nematodirus, Bunostomum, Oesophagostomum, Chabertia, and Haemonchus contortus in cattle and sheep is 97%~100%. It is also very effective against arthropods such as fly larvae, mites and lice. The efficacy is slightly lower for bats and sheep ked. Ivermectin is also very effective against cicadas and flies breeding in feces. Although the drug cannot immediately kill cicadas, it can affect feeding, molting and oviposition, thereby reducing reproductive capacity. The effect on tsetse flies is similar.

The removal rate of adult and immature worms of Ascaris suum, Hyostrongylus rubidus, Globocephalus urosubulatus, Oesophagostomum dentatum, Oesophagostomum quadrispinulatum, Metastrongylus spp. in pigs reaches 94%~100%, and it is also very effective against Trichinella spiralis in the intestine (ineffective against Trichinella spiralis in muscle), and has a good control effect on pig lice and pig mange mites. Ineffective against flukes and tapeworms.

Pharmacokinetics: The pharmacokinetics of ivermectin vary significantly depending on the animal species, dosage form and route of administration. The bioavailability of subcutaneous injection is higher than that of oral administration, but oral administration is faster than subcutaneous injection. After absorption, it can be well distributed to most tissues, but it is not easy to enter the cerebrospinal fluid. The apparent volume of distribution in cattle, sheep and pigs is 0.45~2.4L/kg, 4.6L/kg and 4L/kg, respectively. It has a long half-life in most animals, 2~3 days, 2~7 days and 0.5 days for cattle, sheep and pigs, respectively. This product is metabolized in the liver, mainly hydroxylated in cattle and sheep, and methylated in pigs. It is mainly excreted in feces, and less than 5% is excreted in urine in the form of original form or metabolites. Up to 5% of the administered dose is excreted in milk in lactating animals.

【Drug interactions】Concurrent use with ethacridine may cause serious or fatal encephalopathy.

【Actions and uses】Macrolide antiparasitic drug. Used to prevent and treat livestock nematode diseases, mite diseases and other parasitic insect diseases.

【Usage and dosage】Subcutaneous injection: Single dose, per 1kg body weight, cattle and sheep 0.02ml; pigs 0.03ml.

【Adverse reactions】
(1) When used to treat bovine hypodermosis, if the killed larvae are in key areas, it will cause serious adverse reactions.
(2) During injection, there is discomfort or temporary edema at the injection site.

【Precautions】
(1) Cattle and sheep whose milk is used for human consumption should not be used during lactation.
(2) Each subcutaneous injection point should not exceed 10ml.
(3) Ivermectin is highly toxic to shrimp, fish and aquatic organisms. Do not contaminate water sources with residual drugs and packaging.

【Withdrawal period】Cattle and sheep 35 days, pigs 28 days.

【Specifications】Calculated as Ivermectin (H₂B₁₄ + H₂B₁₅) 100ml:1000mg

【Packaging】100ml×90 bottles/box

【Storage】Protect from light, seal and store in a dry place.

【Shelf life】Two years